Publications
- Haimov I, Laudon M, Zisapel N, Souroujon M, Nof D, Schlitner A, Lavie P.
The relationship between urinary 6 sulfatoxy melatonin rhythm and insomnia in old age.
Adv. Pin. Res. 8: 433-438 (1994). - Haimov I, Laudon M, Zisapel N, Souroujon M, Nof D, Shlitner A, Herer P, Tzischinsky O, Lavie P.
Sleep disorders and melatonin rhythms in elderly people.
Brit. Med. J. 309: 167-168 (1994). Read more - Haimov I, Lavie P, Laudon M, Herer P, Vigder C, Zisapel N.
Melatonin replacement therapy of elderly insomniacs.
Sleep 18: 598-603 (1995). Read more - Garfinkel D, Laudon M, Nof D, Zisapel N.
Improvement of sleep quality in elderly people by controlled release melatonin.
The Lancet 364: 541-544 (1995). Read more - Laudon M, Gilad E, Matzkin H, Braf Z, Zisapel N.
Putative melatonin receptors in benign human prostate tissue.
J. Clin Endocrinol. Metab. 81:1336-1342 (1996). Read more - Gilad E, Laudon M, Matzkin H, Pick E, Sofer M, Braf Z, Zisapel N.
Functional melatonin receptors in human prostate epithelial cells.
Endocrinology 137;1412-1417 (1996). Read more - Atsmon J, Oaknin S, Laudon M, Laschiner S, Gavish M, Dagan Y, Zisapel N.
Reciprocal effects of chronic diazepam and melatonin on brain melatonin and benzodiazepine binding sites.
J. pineal Res. 20: 65-71 (1996). Read more - Garfinkel D, Zisapel N.
Liver cirrhosis and circadian rhythm.
Annals Int. Med. 125:154 (1996). Read more - Laudon M, Tarasch R, Zisapel N.
Effects of fast and slow release melatonin formulations on daytime sleep and mood.
Pineal update-from molecular mechanisms to clinical implications (SM Webb, M Puig-Domingo, M. Moller and P Pevet eds) PJD Publicatons NY (1997). - Garfinkel D, Laudon M, Zisapel N.
Improvement of sleep quality by controlled-release melatonin in benzodiazepine treated elderly insomniacs.
Arch. Gerontol. Geriat. 24:223-231 (1997). Read more - Terlo L, Laudon M, Tarasch R, Schatz T, Caine YG, Zisapel N.
Effects of low doses of melatonin on late afternoon napping and mood.
Biol. Rhythm. Res. 28:2-16 (1997). Read more - Dagan Y, Zisapel N, Nof D, Laudon M, Atsmon J.
Rapid reversal of tolerance to benzodiazepine hypnotics by treatment with oral melatonin: a case report.
Eur. Neuropsychpharmacol. 7:157-160 (1997). Read more - Zisapel N, Garfinkel D.
Use of controlled release melatonin for insomnia in older persons.
Clinical Geriatrics 5:17-27 (1997). - Garfinkel D, Zisapel N.
The use of melatonin for sleep.
Nutrition (editorial) 14:53-55 (1998). Read more - Bubenik GA, Blask DE, Brown GM, Maestroni GJ, Pang SF, Reiter RJ, Viswanathan M, Zisapel N.
Prospects of the clinical utilization of melatonin.
Biol Signals Recept 7;195-219 (1998). Read more - Laudon M, Zisapel N.
Melatonin deficiency and its implications for the treatment of insomnia in elderly subjects.
The Aging Male 1:244-253 (1998). Read more - Zisapel N.
The use of melatonin in the treatment of insomnia.
Biol Signals Recept. 8:84-89 (1999). Read more - Garfinkel D, Zisapel N, Wainstein J, Laudon M.
Facilitation of benzodiazepine discontinuation by melatonin: a new clinical approach.
Arch. Int. Med 159:2456-60 (1999). Read more - Zisapel N.
Development of a melatonin based formulation for the treatment of insomnia.
Drug Dev Res 50:226-234 (2000). - Shamir E, Laudon M, Barak Y, Anis Y, Rotenberg V, Elizur A, Zisapel N.
Melatonin improves sleep quality of chronic schizophrenic patients.
Journal Clin. Psychiatry 61:373-378 (2000). Read more - Sivan Y, Laudon M, Kuint J, Zisapel N.
Low melatonin production in infants with a life threatening event.
Dev Med Child Neurol 42: 487-491(2000). Read more - Shamir E, Laudon M, Barak Y, Anis Y, Rotenberg V, Elizur A, Zisapel N.
First night effect under melatonin treatment of patients with chronic schizophrenia.
J. Clin Psychopharmacology 20:691-694 (2000). Read more - Shamir E, Barak Y, Plopsky I, Zisapel N, Elizur A, Weizman A.
Is melatonin treatment effective for tardive dyskinesia?
J Clin Psychiat 61:556-558 (2000). Read more - Zisapel N.
Circadian Rhythm Sleep Disorders: Pathophysiology and Potential Approaches to Management.
CNS Drugs 15:311-328 (2001). Read more - Sivan Y, Laudon M, Tauman R, Zisapel N.
Melatonin production in healthy infants: Evidence for seasonal variations.
Pediatric Res 49:63-68 (2001). Read more - Shamir E, Barak Y, Shalman I, Laudon M, Zisapel N, Tarrasch R, Elizur A, Weizman R.
Melatonin treatment for tardive dyskinesia: a double-blind, placebo-controlled, crossover study. Arch Gen Psychiatry 58:1049-1052 (2001). Read more - Zisapel N.
Melatonin-Dopamine Interactions: From Basic Neurochemistry to a Clinical Setting.
Molec Cell Neurobiol. 21:605-616 (2001). Read more - Beloosesky Y, Grinblat J, Laudon M, Grosman B, Streifler JY, Zisapel N.
Melatonin rhythms in stroke patients.
Neurosci Lett 319:103-6 (2002). Read more - Tauman R, Zisapel N, Laudon M, Nehama H, Sivan Y.
Melatonin production in infants: association with perinatal and postnatal factors.
Pediat. Neurol. 26:379-82 (2002). Read more - Zisapel N, Laudon M.
Subjective Assessment of the Effects of CNS-Active Drugs on Sleep by The Leeds Sleep Evaluation Questionnaire: A Review.
Human Neuropsychopharmacology: clinical & experimental 18:1-20 (2003). Read more - Jonas M, Garfinkel D, Zisapel N, Laudon M, Grossman E.
Impaired Nocturnal melatonin Secretion in non-dipper hypertensive patients.
Blood Press. 12:1-6 (2003). Read more - Leppämäki S, Partonen T, Vakkuri O, Lönnqvist J, Partinen M, Laudon M.
Effect of controlled-release melatonin on sleep quality, mood, and quality of life in subjects with seasonal or weather-associated changes in mood and behaviour.
Eur Neuropsychopharmacol. 12:137-45 (2003). Read more - Tarrasch R, Laudon M, Zisapel N.
Cross-cultural validation of the Leeds sleep evaluation questionnaire (LSEQ) in insomnia patients.
Hum Psychopharmacol. 18:603-10 (2003). Read more - Zisapel N, Nir T.
Determination of the minimal clinically significant difference on a patient visual analog sleep quality scale.
Sleep Res. 12:291-8 (2003). Read more - Leger D, Laudon M, Zisapel N.
Nocturnal 6-sulfatoxymelatonin excretion in insomnia and its relation to the response to melatonin replacement therapy.
Am J Med. 116:91-5 (2004). Read more - Pandi-Perumal SR, Zisapel N, Srinivasan V, Cardinali DP.
Melatonin and sleep in aging population.
Exp Gerontol. 40:911-25 (2005). Read more - Grossman E, Laudon M, Yalcin R, Zengil H, Peleg E, Sharabi Y, Kamari Y, Shen-Orr Z, Zisapel N.
Melatonin reduces night blood pressure in patients with nocturnal hypertension.
Am J Med. 119:898-902 (2006). Read more - Gorfine T, Assaf Y, Goshen-Gottstein Y, Yeshurun Y, Zisapel N.
Sleep-anticipating effects of melatonin in the human brain.
Neuroimage. 31:410-8 (2006). Read more - Gorfine T, Zisapel N.
Melatonin and the human hippocampus, a time dependent interplay.
J Pineal Res. ;43:80-6 (2007). Read more - Zisapel N.
Sleep and sleep disturbances: biological basis and clinical implications.
Cell Mol Life Sci. (2007). Read more - Wade AG, Ford I, Crawford G, McMahon AD, Nir T, Laudon M, Zisapel N.
Efficacy of prolonged release melatonin in insomnia patients aged 55–80 years: quality of sleep and next-day alertness outcomes.
Current Medical Research and Opinion. 23: 2597–2605 (2007). Read more - Gorfine T, Yeshurun Y, Zisapel N.
Nap and melatonin-induced changes in hippocampal activation and their role in verbal memory consolidation.
J Pineal Res.;43:336-42 (2007). Read more - Lemoine P, Nir T, Laudon M, Zisapel N.
Prolonged-release melatonin improves sleep quality and morning alertness in insomnia patients aged 55 years and older and has no withdrawal effects.
J. Sleep Res. 16:372-380 (2007). Read more - Otmani S, Demazières A, Staner C, Jacob N, Nir T, Zisapel N, Staner L.
Effects of prolonged-release melatonin, zolpidem, and their combination on psychomotor functions, memory recall, and driving skills in healthy middle aged and elderly volunteers.
Hum Psychopharmacol 2008;23(8):693-705. Read more - Wade AG, Zisapel N, Lemoine P.
Prolonged-release melatonin for the treatment of Insomnia: targeting quality of sleep and morning alertness.
Aging Health 2008;1:11-21. Read more - Zisapel N, Lemoine P.
Efficacy and Safety of Circadin® in the Treatment of Primary Insomnia. Touchbriefings 2008. - Luthringer R, Muzet M, Zisapel N, Staner L.
The effect of prolonged-release melatonin on sleep measures and psychomotor performance in elderly patients with insomnia.
Int Clin Psychopharmacol 2009 Sep;24(5):239-49. Read more - Wade AG, Ford I, Crawford G, McConnachie A, Nir T, Laudon M, Zisapel N.
Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety.
BMC Med 2010;8(1):51. Read more - Wade AG, Crawford G, Ford I, McConnachie A, Nir T, Laudon M, Zisapel N.
Prolonged Release Melatonin in the treatment of Primary Insomnia – Evaluation of the Age Cut-off for short and long-term response.
CMRO 2011;27(1):87-98. Read more - De Leersnyder H, Zisapel N, Laudon M.
Prolonged-release melatonin for children with neurodevelopmental disorders.
Pediatr Neurol. 2011 Jul;45(1):23-6. Read more - Lemoine P, Garfinkel D, Laudon M, Nir T, Zisapel N.
Prolonged-release melatonin for insomnia – an open-label long-term study of efficacy, safety, and withdrawal.
Ther Clin Risk Manag. 2011 Jul;7:301-11. Read more - Garfinkel D, Zorin M, Wainstein J, Matas Z, Laudon M, Zisapel N.
Efficacy and safety of prolonged-release melatonin in insomnia patients with diabetes: a randomized, double-blind, crossover study.
Diabetes Metab Syndr Obes. 2011;4:307-13. Read more - Grossman E, Laudon M, Zisapel N.
Effect of melatonin on nocturnal blood pressure: meta-analysis of randomized controlled trials.
Vasc Health Risk Manag. 2011;7:577-84. Read more / Watch video - Kunz D, Bineau S, Maman K, Milea D, Toumi M.
Benzodiazepine discontinuation with prolonged-release melatonin: hints from a German longitudinal prescription database.
Expert Opin Pharmacother. 2012 Jan;13(1):9-16. Read more - Lemoine P, Wade AG, Katz A, Nir T, Zisapel N.
Efficacy and safety of prolonged-release melatonin for insomnia in middle-aged and elderly patients with hypertension: a combined analysis of controlled clinical trials.
Integr Blood Press Control. 2012;5:9-17. Read more - Otmani S, Metzger D, Guichard N, Danjou P, Nir T, Zisapel N, Katz A.
Effects of prolonged-release melatonin and zolpidem on postural stability in older adults.
Hum Psychopharmacol. 2012 Feb 20. Read more
